Endocrine Abstracts

Introduction: Pituitary gigantism is a rare disorder characterized by growth hormone (GH) excess that occurs before epiphyseal growth plates fusion leading to rapid and excessive linear growth in childhood and very tall adult stature. It can be sporadic or coexist with genetic disorders such as FIPA, X-LAG, McCune-Albright, Carney complex, MEN 1 or 4, and Neurofibromatosis type 1.Case report: We present a case of a 12 years old boy with no medical histor...

Background: Metabolomics profiling of bio-fluids suggests altered signatures in patients with the polycystic ovary syndrome (PCOS).Subjects and methods: A high-performance liquid chromatography/time-of-flight mass spectrometry (HPLC/TOF-MS)-based metabolomics approach was developed to characterize the untargeted lipidomics signature associated with PCOS status in a discovery cohort of 30 plasma samples (15 PCOS, 15 controls, age-matched), followed in a s...

Depression can be an early manifestation of Cushing Syndrome (CS) and found to correlate with the severity of the clinical presentation. Rates for major depression vary from 12% to 50–70%. A 37-year-old male was admitted for sad mood, affective lability, suicidal ideation without a plan and micromanian incurability ideation. The medical history of the patient revealed an old anterior-lateral myocardial infarction last year, with percutaneous coronary intervention on diago...

Adrenal incidentalomas (prevalence between 0.4 and 7%) have become a very common clinical problem, the major concern being the risk of malignancy and hormone overproduction.A 57-year-old woman was admitted for asthenia and uncontrolled hypertension. The only relevant clinical signs were abdominal obesity (BMI=31.1 kg/m2) and hypertension. Abdominal ultrasonography showed a voluminous left adrenal solid mass of 10/9 cm, with well-defined sharp ...

Multiple endocrine neoplasia 2A (MEN2A), an autosomal dominant genetic syndrome caused by germline mutation in RET proto-oncogene, associates medullary thyroid carcinoma (MTC), pheochromocytoma (PHEO) and primary hyperparathyroidism (HPT). Thyroid hemiagenesis (TH), the absence of one lobe, is a rare congenital abnormality (300 cases are reported in literature). Most cases of TH are diagnosed when patients present a lesion in the functioning lobe. TH was observed among members...

Introduction: Primary aldosteronism (PA) is an important cause of secondary hypertension, associated with increased cardiovascular morbidity and mortality rate compared to patients with essential hypertension.Case report: We report the case of a 59-year-old Caucasian male with a medical history of dilatative cardiomiopathy, paroxysmal atrial fibrillation and bifascicular block who was admitted to the E.R. with shortness of breath, headache, palpitations,...

Hyperthyroidism in the course of Graves’ disease leads to intensification of oxidative processes resulting in increased oxidative stress.Objectives: The effect of supplementation with vitamin E was monitored on the speed of attaining euthyroidism and on the oxidative stress parameters in patients with Graves’ disease, treated with thiamazole.Patients and methods: We examined 43 hyperthyroid patients and 12 euthyroid healt...

Autoimmune Polyglandular Syndrome Type I (APS 1) is a rare monogenic disease, in which simultaneous or sequential dysfunctions of endocrine or nonendocrine glands appear. A 19-year-old woman was admitted for inappetence, nausea, vomiting, abdominal pain, chronic constipation, generalized paresthesia and vertigo. She was known with primary hypoparathyroidism (from the age of 5), chronic autoimmune thyroiditis, mucocutaneous candidiasis, under treatment with calcitriol, calcium,...

Primary hyperparathyroidism (PHPT) is rarely associated with the development of acute pancreatitis (AP). The incidence of AP induced by hypercalcemia in PHPT varies between 1.5 and 7%. PHPT is most commonly caused by parathyroid adenoma and infrequently by parathyroid hyperplasia, carcinoma or cyst and multiple endocrine neoplasia (MEN) types 1 and 2A. The present case is a 48-year-old man referred to our service for further investigation 1 month after an acute hemorrhagic nec...

Background: Adequate and appropriate nutrition in type 1 diabetic athletes is essential not only to increase the physical performance but also to prevent the hypoglycemic events. Detailed nutrition history represents the initial step in developing a proper meal plan according to the specific characteristics of the physical activity performed.Purpose: This study assessed changes in habitual dietary intake and macronutrient distribution in response to inte...